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Related Kaempferia parviflora articles

Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora

Pattara Sawasdee Chalisa Sabphon Duangporn Sitthiwongwanit Udom Kokpol

The rhizome of Kaempferia parviflora or kra?chai?dum (in Thai) is used traditionally as a folk medicine. The preliminary cholinesterase inhibitory screening of this plant extract exhibited significant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. Thirteen known methoxyflavones (1–13) were isolated and their structures were completely elucidated based on NMR analysis and compared with literature reports. Minor compounds 12–13 were reported for the first time from this species. The cholinesterase inhibitory test results showed that the highest potential inhibitors toward AChE and BChE were 5,7,4??trimethoxyflavone (6) and 5,7?dimethoxyflavone (7), respectively, with the percentage inhibitory activity varying over 43–85%. The structure?activity relationship study led to the conclusion that compounds bearing 5,7?dimethoxy groups and a free substituent at C?3 had a significant inhibitory effect at a concentration of 0.1 mg/mL, but those bearing a 5?hydroxyl group reduced the inhibitory potency. On the other hand, flavones bearing a 3?? or 5??methoxy group did not influence the inhibitory effect. Interestingly, 5,7?dimethoxyflavone (7) exhibited strong selectivity for BChE over AChE which may be of great interest to modify as a treatment agent for Alzheimer's disease.


Our kaempferia parviflora extract

Dosage advice




Capsules


Kaempferia parviflora extract, 400 capsules @ 300 mg, $120



Kaempferia parviflora extract, 400 capsules @ 300 mg, plus mucuna pruriens extract 100 capsules @ 300 mg, $132



Kaempferia parviflora extract, 400 capsules @ 300 mg, plus mucuna pruriens extract 100 capsules @ 300 mg, plus boesenbergia rotunda extract 100 capsules @ 300 mg, $144



Kaempferia parviflora extract, 800 capsules @ 300 mg, $216



Kaempferia parviflora extract, 800 capsules @ 300 mg, plus mucuna pruriens extract 200 capsules @ 300 mgg, $238



Kaempferia parviflora extract, 800 capsules @ 300 mg, plus mucuna pruriens extract 200 capsules @ 300 mg, plus boesenbergia rotunda extract 200 capsules @ 300 mg, $260



Kaempferia parviflora extract, 1600 capsules @ 300 mg, $388



Kaempferia parviflora extract, 1600 capsules @ 300 mg, plus mucuna pruriens extract 400 capsules @ 300 mg, $428



Kaempferia parviflora extract, 1600 capsules @ 300 mg, plus mucuna pruriens extract 400 capsules @ 300 mg, plus boesenbergia rotunda extract 400 capsules @ 300 mg , $428




Extract pouches


Dosage advice

Kaempferia parviflora extract, 2 pouches @ 75 grams, $120



Kaempferia parviflora extract, 4 pouches @ 75 grams, $216



Kaempferia parviflora extract, 4 pouches @ 75 grams, plus mucuna pruriens extract 1 pouch @ 75 grams, $238



Kaempferia parviflora extract, 4 pouches @ 75 grams, plus mucuna pruriens extract 1 pouch @ 75 grams, plus boesenbergia rotunda extract 1 pouch @ 75 grams, $260



Kaempferia parviflora extract, 8 pouches @ 75 grams, $388



Kaempferia parviflora extract, 8 pouches @ 75 grams, plus mucuna pruriens extract 2 pouches @ 75 grams, $428



Kaempferia parviflora extract, 8 pouches @ 75 grams, plus mucuna pruriens extract 2 pouches @ 75 grams, plus boesenbergia rotunda extract 2 pouches @ 75 grams, $468